Current Issue : April - June Volume : 2015 Issue Number : 2 Articles : 7 Articles
Medicinal plants have played a key role in world health and promising future. Garcinia indica, a small to moderate size plant belonging to the Clusiaceae family or Guttiferae, according to the old classification, has approximately 1350 species.It has a number of benefits which can be a boon for patients suffering from various ailments.In Ayurveda, Kokum traditionally used for edema, rheumatism, delayed menstruation, constipation, bowel complaints, intestinal parasites, skin rashes and burns. Kokum fruit possess useful antioxidant, chelating, anti-cancer,anti-fungal, anti-inflammatory, anti-bacterial, cardio protective and anti-ulcer activities. The peel of this fruit contains the highest proportion of xanthones which can be beneficial for the body as a whole....
Plumericin, an iridoid lactone, was isolated with relatively high yield from Momordica charantia vine using the supercritical fluid\nextraction (SFE) and the separation box (Sepbox) comprising dual combination of high-performance liquid chromatography\nand solid phase extraction. This compound showed antibacterial activity against Enterococcus faecalis and Bacillus subtilis with\nminimum inhibitory concentration (MIC) values better than cloxacillin. Plumericin potently inhibited proliferation of two\nleukemic cancer cell lines: they were acute and chronic leukemic cancer cell lines, NB4 and K562, with the effective doses (ED50)\nof 4.35 �± 0.21 and 5.58 �± 0.35 ????g/mL, respectively. In addition, the mechanism of growth inhibition in both cell lines was induced\nby apoptosis, together with G2/M arrest in K562 cells....
Phytochemicals have been presumed to possess prophylactic and curative properties in several pathologies, such as arsenic- (As-)\ninduced immunosuppression. Our aim was to discover a lymphoprotective extract from Lantana grisebachii Stuck. (Verbenaceae)\n(LG). We assessed its bioactivity and chemical composition using cell-based assays. Fractions produced from a hexane extract\nacutely induced nitrite formation in T-activated cell cultures (P < 0.0001). Water extraction released a fraction lacking nitrite\ninducing activity in both lymphocyte types. Aqueous LG was found to be safe in proliferated and proliferating cells. The\ninfusion-derived extract presented better antioxidant capacity in proportion to phenolic amount in lymphocytes (infusive LG-\n1i at 100 ?g/mL), which protected them against in vitro As-induced lymphotoxicity (P < 0.0001). This infusive LG phytoextract\ncontained 10.23 �± 0.43mg/g of phenolics, with 58.46% being flavonoids. Among the phenolics, the only predominant compound\nwas 0.723mg of chlorogenic acid per gram of dry plant, in addition to 10 unknown minor compounds. A fatty acid profile was\nassessed. It contained one-third of saturated fatty acids, one-third of ?9, followed by ?6 (?24%) and ?3 (?4%), and scarce ?7.\nSumming up, L. grisebachii was a source of bioactive and lymphoprotective compounds, which could counteract As-toxicity. This\nsupports its phytomedical use and research in order to reduce As-related dysfunctions....
Muscle atrophy, a reduction of muscle mass, strength, and volume, results from reduced muscle use and plays a key role in various\nmuscular diseases. In the microgravity environment of space especially,muscle atrophy is induced by muscle inactivity. Exposure to\nmicrogravity induces muscle atrophy through several biological effects, including associations with reactive oxygen species (ROS).\nThis study used 3D-clinostat to investigate muscle atrophy caused by oxidative stress in vitro, and sciatic denervation was used to\ninvestigate muscle atrophy in vivo.We assessed the effect of Oenothera odorata root extract (EVP) on muscle atrophy. EVP helped\nrecover cell viability in C2C12 myoblasts exposed to microgravity for 24 h and delayed muscle atrophy in sciatic denervated mice.\nHowever, the expressions of HSP70, SOD1, and ceramide in microgravity-exposed C2C12myoblasts and in sciatic denervated mice\nwere either decreased or completely inhibited.These results suggested that EVP can be expected to have a positive effect on muscle\natrophy by disuse and microgravity. In addition, EVP helped characterize the antioxidant function in muscle atrophy....
Dendrobium species, commonly known as ââ?¬Å?Shihuââ?¬Â or ââ?¬Å?Huangcao,ââ?¬Â represents the second largest genus of Orchidaceae, which are\nused commonly as tonic herbs and healthy food in many Asian countries. The aim of this paper is to review the history, chemistry,\nand pharmacology of different Dendrobium species on the basis of the latest academic literatures found in Google Scholar, PubMed,\nSciencedirect, Scopus, and SID....
Green tea and hibiscus are widely consumed as traditional beverages in Yemen and some regional countries. They are relatively\ncheap and the belief is that they improve health state and cure many diseases. The aim of this study was to evaluate the potential\nprotective and antibacterial activity of these two famous plants in vitro through measuring their antibacterial activity and in vivo\nthrough measuring nonenzymatic kidney markers dysfunction after induction of nephrotoxicity by gentamicin. Gram positive\nbacteria like MRSA (methicillin resistant Staphylococcus aureus) were isolated from hospitalized patientsâ�� different sources (pus\nand wound) and Gram negative bacteria including E. coli and P. aeruginosa were used in vitro study. In addition, the efficacy of\nthese plants was assessed in vivo through measuring nonenzymatic kidney markers including S. creatinine and S. urea. Green tea\nwas shown antimicrobial activity against MRSA with inhibition zone 19.67 �± 0.33mm and MIC 1.25 �± 0.00mg/mL compared with\nstandard reference (vancomycin) 18.00 �± 0.00mg/mL.Hibiscus did not exhibit a similar effect. BothHibiscus- and green tea-treated\ngroups had nephroprotective effects as they reduced the elevation in nonenzymatic kidney markers. We conclude that green tea\nhas dual effects: antimicrobial and nephroprotective....
Indigofera aspalathoides and Indigofera tinctoria are the medicinally important plants with remarkable healing potential. These medicinal plants are the potential source of bioactive constituents with their potential therapeutic properties. This study was carried to ascertain the qualitative and quantitative presence of various phytochemical compounds and to identify the functional groups present in the phytochemical compounds of two medicinal plants. The preliminary screening revealed the presence of alkaloids, flavonoids, terpenoids, tannins and cardiac glycosides in the aqueous extract of Indigofera tinctoria and Indigofera aspalathoides. However, steroids were detected only in the aqueous extract of Indigofera aspalathoides. The quantitative analysis revealed significant quantities of phenol and other secondary metabolites in the two plants. The FT IR spectral analysis revealed the presence of functional groups such as alkanes, alcohols, phenols, aldehydes, ketones, amines and carboxylic acids....
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